Author

Cissy Yong

University of CambridgeORCID 0000-0002-8697-1494Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Anna C. ObenaufiD· 1 shared Anna Dyas· 1 shared Daniel Muñoz‐EspíniD· 1 shared Grant Duncan StewartiD· 1 shared Jarno DrostiD· 1 shared Jianfeng GeiD· 1 shared Leticia CastilloniD· 1 shared Ludovic Wesolowski· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Anna C. ObenaufORCID

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1 paper

Recent·Most cited

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities

Jianfeng Ge, Shoko Hirosue, Leticia Castillon, Saroor A. Patel, Ludovic Wesolowski, Anna Dyas, Cissy Yong, Sanne de Haan, Jarno Drost, Grant Duncan Stewart, Anna C. Obenauf, Daniel Muñoz‐Espín, Sakari Vanharanta

This study identifies HIF1A as a key inhibitor of VHL null cell fitness and shows that combined VHL/HIF1A inactivation can confer resistance to PROTAC-based therapies.

EMBO Molecular Medicine · Dec 19, 2025Peer-reviewedCancer Biology