Michella Khoury Damaa

Cyclin O is necessary for multiciliated cells to enter their differentiation cell cycle variant and allows the massive amplification of centrioles, which serve as basal bodies for cilia nucleation.

The paper identifies a new cell cycle variant in multiciliated cells that enables centriole amplification without DNA replication or mitosis.

This study shows that actin-based nuclear deformations are essential for multiciliated ependymal cell differentiation in mice.