Jacques Serizay

Chromatin is dispensable for bacterial life

This study deletes nine NAPs from E. coli to create a strain lacking native chromatin, revealing gene expression homogenization and demonstrating that bacterial life can proceed without chromatin proteins.

Multi-modal data integration for machine learning applications

The paper introduces momics, a framework for integrating multi-omics genomic data, showing improved compression, speed, and performance in deep learning for chromatin accessibility prediction.

Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation

Cyclin O is necessary for multiciliated cells to enter their differentiation cell cycle variant and allows the massive amplification of centrioles, which serve as basal bodies for cilia nucleation.

Micro-C reveals MORC/ApiAP2-mediated links between distant, functionally related genes in the human malaria parasite

The paper uses Micro-C to map DNA-DNA contacts in Plasmodium falciparum, revealing heterochromatic and euchromatic structures mediated by MORC/ApiAP2 and other factors.

Epigenomics coverage data extraction and aggregation in R with tidyCoverage

The paper introduces the tidyCoverage R package for managing and analyzing epigenomic coverage data, enhancing reproducibility and accessibility in genome-wide analysis workflows.

The tidyomics ecosystem: Enhancing omic data analyses

The paper introduces tidyomics, an ecosystem bridging Bioconductor and tidy R to streamline omic analysis using data from the Human Cell Atlas.

Identification of a new cell cycle variant during multiciliated cell differentiation

The paper identifies a new cell cycle variant in multiciliated cells that enables centriole amplification without DNA replication or mitosis.

The cell cycle variant in multiciliated cells incorporates 2 centriole biogenesis cycles

This study shows the MCC cell cycle variant accelerates centriole biogenesis by overlapping two cycles to produce multiple mature centrioles without cell division.

Exogenous chromosomes reveal how sequence composition drives chromatin assembly, activity, folding and compartmentalization

This study shows that bacterial chromosomes can undergo chromatin assembly, activity, looping, and compartmentalization in yeast, driven by their sequence composition.

Tissue-specific profiling reveals distinctive regulatory architectures for ubiquitous, germline and somatic genes

The paper identifies distinct regulatory architectures for ubiquitous, germline, and somatic genes in C. elegans by analyzing promoter features across five tissues.

An Xist-dependent protein assembly mediates Xist localization and gene silencing

The paper shows that Xist RNA forms a protein condensate with binding proteins to establish the Xi-compartment and maintain gene silencing.

Chromatin accessibility is dynamically regulated across C. elegans development and ageing

The paper maps regulatory elements across C. elegans development and ageing, identifying promoters and enhancers and showing their dynamic accessibility linked to developmental processes.