Marion Faucourt

Chemical inhibition of Exon Junction Complex assembly impairs mRNA localization and neural stem cells ciliogenesis

This study shows that inhibiting EJC assembly with EJC-i disrupts mRNA localization and neural stem cell ciliogenesis by affecting multiple post-transcriptional processes.

Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation

Cyclin O is necessary for multiciliated cells to enter their differentiation cell cycle variant and allows the massive amplification of centrioles, which serve as basal bodies for cilia nucleation.

Identification of a new cell cycle variant during multiciliated cell differentiation

The paper identifies a new cell cycle variant in multiciliated cells that enables centriole amplification without DNA replication or mitosis.

Intrinsic microtubule destabilization of multiciliated choroid plexus epithelial cells during postnatal lifetime

The paper shows that choroid plexus cilia undergo axoneme resorption through microtubule destabilization, controlled by polyglutamylation and spastin, and is conserved in human samples.

Actin-based deformations of the nucleus control multiciliated ependymal cell differentiation.

This study shows that actin-based nuclear deformations are essential for multiciliated ependymal cell differentiation in mice.