Author

Mikhail A. Skutel

Skolkovo Institute of Science and TechnologyORCID 0009-0002-1351-3238Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

Artem B. IsaeviD· 2 shared Konstantin SeverinoviD· 2 shared Aleksandr A. ShenfeldiD· 1 shared Alena DrobiazkoiD· 1 shared Alexey A. GavriloviD· 1 shared Alina Demkina· 1 shared Anna B. TrofimovaiD· 1 shared Anton DerzhaeviD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Artem B. IsaevORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 10, 2026

OLD sentinel: an abortive tRNase surveys phage replication and DNA defects in RecBCD-compromised cells

Anton Derzhaev, Jing Zhang, Alexey A. Gavrilov…·Artem B. Isaev

This paper characterizes OLD, an abortive immunity protein, revealing its structure and activation mechanism in response to phage replication and DNA defects in RecBCD-compromised cells.

DOI 10.64898/2026.07.10.737580

experimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedFeb 20, 2025

Molecular basis of foreign DNA recognition by BREX anti-phage immunity system

Alena Drobiazko, Myfanwy C. Adams, Mikhail A. Skutel…·Artem B. Isaev

This study elucidates the molecular mechanism of BREX anti-phage immunity by showing how BrxX methyltransferase recognizes DNA and forms an immune complex to protect against phage infection.

28 citationstop 1%

E. coliDNA methylation

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