OLD sentinel: an abortive tRNase surveys phage replication and DNA defects in RecBCD-compromised cells
Anton Derzhaev, Jing Zhang, Alexey A. Gavrilov, Svetlana Belukhina, Aleksandr A. Shenfeld, Florence Depardieu, Baptiste Saudemont, Ilya Shamovsky, Vitaly Epshtein, Alina Demkina, Huaile Song, Olga Yu. Burenina, Mikhail A. Skutel, Maria A. Tikhomirova, Vadim Molodtsov, , Artem B. Isaev
This paper characterizes OLD, an abortive immunity protein, revealing its structure and activation mechanism in response to phage replication and DNA defects in RecBCD-compromised cells.
bioRxiv · Jul 10, 2026 · PreprintMolecular Biology