Cade Mirchandani

The paper estimates an extreme transmission bottleneck in a deep-sea clam symbiosis using ultra-accurate sequencing, finding an effective bottleneck size of about eight symbionts per host generation.

This study shows Wolbachia infection changes host cell states in Drosophila cell lines, affecting gene expression and chromatin structure, and suggests these changes determine symbiotic outcomes.

The paper introduces clam, a tool that efficiently estimates nucleotide diversity and divergence using variant-only VCFs and callable loci, improving computational performance and storage.

This study shows that the wMel Wolbachia strain outcompetes the promiscuous wRi strain in vitro across different host cell types, suggesting a deterministic outcome that may explain low natural mixed infections.

This paper introduces snpArcher, a variant calling workflow for non-model organisms, and applies it to 26 public datasets to enable comparative population genomic analyses.