Mattia Brugiolo

This study shows that ultraconserved poison exons regulate mitotic splicing fidelity and stem cell viability by controlling SR protein levels and splicing networks.

SpliceDecoder prioritizes biologically meaningful splicing events by predicting their impact on transcript productivity, protein sequence, and functional domains.

The paper identifies intron retention in STAT2 as a regulator of immune signaling and a predictor of immunotherapy response in lung cancer.

Cellos is a high-throughput image analysis pipeline for 3D organoid segmentation and analysis, enabling accurate quantification of drug responses and cell interactions in cancer organoids.