Xinhao Hou

This study identifies SET-19 as a somatic H3K23 methyltransferase in C. elegans and shows its role in gene repression through chromatin modifications.

The paper shows that spatial clustering of piRNA genes in nematodes enhances transcription through phase separation involving UAD-2 and the SUMO regulatory factors GEI-17 and TOFU-3.

The paper systematically characterizes chromodomain proteins in C. elegans, identifying CEC-5 as an H3K9me1/2 reader that regulates aging through interactions with MET-2.

This study shows that mutations in H3K9me1/2 methyltransferase genes synergistically extend lifespan in C. elegans daf-2 mutants, enhancing stress resistance through DAF-16 activation.