Spatially clustered piRNA genes promote the transcription of piRNAs via condensate formation of the H3K27me3 reader UAD-2
Chengming Zhu, Xiaoyue Si, Xinhao Hou, Panpan Xu, Jianing Gao, Yao Tang, Chenchun Weng, Mingjing Xu, Qi Yan, Qile Jin, Jiewei Cheng, Ke Ruan, Ying Yin Zhou, Ge Shan, Demin Xu, , Shouhong Guang
The paper shows that spatial clustering of piRNA genes in nematodes enhances transcription through phase separation involving UAD-2 and the SUMO regulatory factors GEI-17 and TOFU-3.
Nature Structural & Molecular Biology · May 2, 2025Peer-reviewedMolecular Biology