Author

Clara Börnsen

Goethe University FrankfurtORCID 0009-0002-5547-6789Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:Arabidopsis· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Achilleas S FrangakisiD· 2 shared Klaas Martinus PosiD· 2 shared Ashwin BalakrishnaniD· 1 shared Attilio Vittorio VargiuiD· 1 shared C Thiel· 1 shared Eiki YamashitaiD· 1 shared Felix LangschiediD· 1 shared Hi-jea Cha· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

Achilleas S FrangakisORCID

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2 papers

Recent·Most cited

Cell-envelope conduits enable transfer of megabase-sized double-stranded DNA between cells of the nosocomial pathogen Acinetobacter baumannii

Sina Manger, Clara Börnsen, Sara Garcia Torres, Pauline Roth, Julian Sommer, Ashwin Balakrishnan, Felix Langschied, C Thiel, Inga Hänelt, Mike Heilemann, Stephan Goettig, Ingo Ebersberger, Klaas Martinus Pos, Achilleas S Frangakis

The paper identifies cell-envelope conduits in Acinetobacter baumannii that enable direct transfer of large chromosomal DNA segments between cells.

bioRxiv · Sep 3, 2026 · PreprintMicrobiology

Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity

Mariya Lazarova, Thomas Eicher, Clara Börnsen, Hui Zeng, Mohd Athar, Ui Okada, Eiki Yamashita, Inga M. Spannaus, Max Borgosch, Hi-jea Cha, Attilio Vittorio Vargiu, Satoshi Murakami, Kay Diederichs, Achilleas S Frangakis, Klaas Martinus Pos

This study shows that a single conserved residue transfer between RND efflux pump clusters alters drug resistance and conformational dynamics.

Nature Communications · Nov 26, 2025Peer-reviewedBiochemistry