Julien Leclercq

A cellular atlas of Astyanax mexicanus embryogenesis reveals principles of developmental microevolution

This study creates a single-nucleus RNA-seq atlas of Astyanax mexicanus embryogenesis, revealing tissue-specific transcriptional tempo shifts and developmental microevolution mechanisms.

Evolution of the regulation of developmental gene expression in blind Mexican cavefish

The paper identifies cis-regulatory changes driving developmental gene expression differences between surface and blind cavefish morphs, with rx3 regulation showing both cis-autonomous and non-autonomous mechanisms.

The enzymatic and neurochemical outcomes of a mutation in Mexican cavefish MAO reveal teleost-specific aspects of brain monoamine homeostasis

This study examines the effects of a mutation in the MAO gene of Mexican cavefish, revealing its impact on monoamine neurotransmitter homeostasis and differences between brain regions.

Awakening adult neural stem cells: NOX signalling as a positive regulator of quiescence to proliferation transition in the Xenopus retina

The paper investigates ROS signaling in Xenopus retinal stem cells, showing NOX promotes quiescence-to-proliferation transition by modulating Wnt/Hedgehog signaling.

Maternally-regulated gastrulation as a source of variation contributing to cavefish forebrain evolution

The paper identifies maternal-regulated gastrulation heterochronies in cavefish that contribute to forebrain evolution by altering gene expression patterns during early development.