Megan C. Steain

This study shows that the conformational state of RIPK3 RHIM domain determines whether it forms reversible condensates or amyloid fibrils, revealing a dual role for phase separation in amyloid formation.

This paper reports the high-resolution structure of a viral:host hetero-amyloid complex between M45 and RIPK3, revealing its mechanism of inhibiting necroptosis.

The paper identifies cyclic peptides that bind RIPK3's RHIM-containing region, enabling visualization of its monomeric and functional amyloid conformations in live cells.

This study develops a chimeric spike antigen vaccine (CoVEXS5) that induces broad immunity against multiple SARS-CoV-2 variants and other sarbecoviruses in animal models.

This study develops an LNP-mRNA vaccine against Mycobacterium tuberculosis that induces strong immune responses and protects mice from infection, with potential for human application.

The paper develops a multiplexed, high-throughput pseudovirus neutralisation assay to measure neutralising antibodies against SARS-CoV-2 variants, showing reliability and consistency across single and multiplexed formats.