Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor- and stem-like cell expansion in the context of ESR1 mutation
Thu Ha Truong, Noelle E. Gillis, Amy R. Dwyer, Rosemary J. Huggins, Kyla M. Hagen, Sai Harshita Posani, Nuri A. Temiz, Carlos Jesus Perez Kerkvliet, Ellie Piepgras, Julie Hanson Ostrander, Geoffrey L. Greene, Carol Ann Lange
This study shows that progesterone receptors (PR) interact with mutant ESR1 variants in ER+ breast cancer, driving CSC expansion and UPR activation, which can be targeted therapeutically.
npj Breast Cancer · Apr 7, 2026Peer-reviewedCancer Biology