Bjoern Kscheschinski

This study shows E. coli rapidly remodels its proteome during early starvation, with gene expression patterns in the first 10 hours determining long-term stress tolerance.

The paper quantifies how growth rate and protein production fluctuations contribute to gene expression noise in E. coli, finding growth rate fluctuations are largely independent and decrease with mean growth rate.

RealTrace is a Bayesian method that removes measurement noise from time-lapse microscopy data to reveal biological dynamics, showing fluctuating growth rates and gene expression in single cells.