David M. Suter

This paper identifies compounds that enhance protein turnover in human neurons using a live-cell imaging platform and validates their efficacy in reducing a-synuclein aggregates.

The paper investigates the distinct roles of SRCAP and H2A.Z in gene regulation during the cell cycle in pluripotent stem cells, revealing SRCAP's H2A.Z-independent inhibitory function and H2A.Z's repressive role in lineage-specific gene expression.

This study investigates how charge, hydrophobicity, and cooperativity affect the target search of SOX2 and ESRRB transcription factors using single-molecule imaging and genomic analysis.

This study shows that the electrostatic properties of disordered regions in transcription factors influence their search efficiency and pioneer activity on chromatin.

The paper investigates how protein synthesis and decay rates are coordinated in mammalian cells, revealing passive and mTOR-dependent mechanisms that maintain proteome stability.

The paper investigates how fluctuations in OCT4, SOX2, and NANOG concentrations affect their genomic binding in mouse embryonic stem cells, revealing distinct concentration-dependent behaviors.

RealTrace is a Bayesian method that removes measurement noise from time-lapse microscopy data to reveal biological dynamics, showing fluctuating growth rates and gene expression in single cells.

This study investigates how pluripotent stem cells reactivate gene expression and rebind transcription factors during mitotic exit using a novel temporal separation method.

This study shows ERK signalling dismantles the naive pluripotent state and preserves pluripotency during transition to formative pluripotency in mouse embryonic stem cells.

The paper uses flux analysis to quantify gene expression dynamics in mouse bone marrow-derived DCs, revealing six regulatory modalities and highlighting protein degradation's role in LPS response.

GEMLI predicts cell lineages from scRNA-seq data without lineage tracing, identifying heritable gene expression and cell fate decisions in various contexts.

This study investigates how OCT4 and SOX2 regulate chromatin accessibility in mouse embryonic stem cells across the cell cycle, showing their independent and cooperative roles in maintaining pluripotency.

The paper shows that fluctuations in OCT4 and SOX2 levels influence cell fate decisions by affecting chromatin accessibility at differentiation enhancers.

The paper quantifies how SMAD4 and SMAD2 dynamics relate to ctgf gene activation kinetics in single cells using live imaging and temporal analysis.

The paper shows that mitotic chromosome binding of transcription factors correlates with their interphase properties and impact on chromatin accessibility.

The paper investigates how NF-kB (p65) DNA binding time relates to transcriptional activation by analyzing mutants affecting DNA binding and protein-protein interaction domains.