Cell BiologyNature CommunicationsPeer-reviewed
Amphipathic helices sense the inner nuclear membrane environment through lipid packing defects
Shoken Lee, Anabel‐Lise Le Roux, Marc C. Goudge…·Shirin Bahmanyar
The paper identifies how amphipathic helices bind to the inner nuclear membrane by sensing lipid packing defects rather than electrostatics, showing the INM's loose packing under basal conditions.
DOI 10.1038/s41467-026-75561-0