Repurposing clofarabine against enteric pathogens via metabolic starvation
Nataya D Deans, Kathryn L. Naylor, Salma Srour, Bani Mallick, Trong Khoa Pham, James W Sheffield, Olivia F Ansell, Caleb D Edington-Siddon, Elena A Burt, Graham P. Stafford, Mark O. Collins, Daniel Humphreys
This study identifies clofarabine as an inhibitor of EPEC pathogenesis by targeting bacterial and host translation, revealing a bacterial mechanism to counteract its effects.
bioRxiv · Oct 10, 2026 · PreprintMicrobiology