Nermeen Fawzy

This study identifies acid phospholipase A1's role in lysosomal glycerophospholipid catabolism and shows its interaction with bis(monoacylglycero)phosphate and inhibition by cationic amphiphilic drugs.

The paper describes a non-canonical phospholipid synthesis pathway catalyzed by CLN8, leading to BMP synthesis and revealing its role in lysosomal lipid homeostasis and Batten disease.

This study identifies cytosolic and secreted transacylases that synthesize bis(monoacylglycero)phosphate (BMP) independently of CLN5, correcting BMP deficiency in CLN5-deficient cells.