Author

Achim Lass

University of GrazORCID 0000-0002-8190-7151Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Anita Pirchheim· 3 shared Clara ZittaiD· 3 shared Dagmar KratkyiD· 3 shared Dominik BulfoniD· 3 shared Johannes BreithoferiD· 3 shared Lennart HartigiD· 3 shared Martin TischitziD· 3 shared Nermeen FawzyiD· 3 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

Anita Pirchheim

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Acid phospholipase A1 promotes lysosomal membrane catabolism

Martin Tischitz, Johannes Breithofer, Dominik Bulfon, Clara Zitta, Amit Singh, Carina Wagner, Nermeen Fawzy, Thomas Züllig, Monika Oberer, Lennart Hartig, Anita Pirchheim, Laszlo Schooltink, Ulrike Taschler, Karl F. Gruber, Achim Lass, , Robert Zimmermann

This study identifies acid phospholipase A1's role in lysosomal glycerophospholipid catabolism and shows its interaction with bis(monoacylglycero)phosphate and inhibition by cationic amphiphilic drugs.

bioRxiv · Aug 7, 2026 · PreprintBiochemistry

CLN8 enables a non-canonical phospholipid synthesis pathway

Johannes Breithofer, Nermeen Fawzy, Clara Zitta, Martin Tischitz, Dominik Bulfon, Clemens Hofmann, Lennart Hartig, Carina Wagner, Gernot F. Grabner, Anita Pirchheim, Achim Lass, Ulrike Taschler, Keira Turner, Kasparas Petkevicius, Ulrich Stelzl, , Robert Zimmermann

The paper describes a non-canonical phospholipid synthesis pathway catalyzed by CLN8, leading to BMP synthesis and revealing its role in lysosomal lipid homeostasis and Batten disease.

bioRxiv · Dec 20, 2025 · PreprintBiochemistry

The endolysosomal phospholipid bis(monoacylglycero)phosphate is synthesized via intra- and extracellular pathways

Dominik Bulfon, Johannes Breithofer, Gernot F. Grabner, Nermeen Fawzy, Anita Pirchheim, Heimo Wolinski, Dagmar Kolb, Lennart Hartig, Martin Tischitz, Clara Zitta, Greta Bramerdorfer, Achim Lass, Ulrike Taschler, Dagmar Kratky, Peter Greimel, Robert Zimmermann

This study identifies cytosolic and secreted transacylases that synthesize bis(monoacylglycero)phosphate (BMP) independently of CLN5, correcting BMP deficiency in CLN5-deficient cells.

Nature Communications · Nov 15, 2024Peer-reviewedBiochemistry