Author

Linxiu Pan

University of MichiganORCID 0009-0003-2474-4944Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:metabolism & bioenergetics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Liangguang Leo LiniD· 2 shared Ling QiiD· 2 shared Xiaoqiong WeiiD· 2 shared Ali NajiiD· 1 shared Anna Chiara RussoiD· 1 shared Brent Pederson· 1 shared Brigid Ellen GreggiD· 1 shared Chengyang LiuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Liangguang Leo LinORCID

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2 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedFeb 25, 2026

SEL1L-HRD1 ER-Associated Degradation Facilitates Prohormone Convertase 2 Maturation and Glucagon Production in Islet α Cells

Wenzhen Zhu, Linxiu Pan, Xianwei Cui…·Rachel B. Reinert

This study identifies SEL1L-HRD1 ERAD as a regulator of PC2 maturation and glucagon production in islet α cells by degrading misfolded proPC2.

1 citation

mouseexperimental assay

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Cell BiologybioRxivPreprintAug 1, 2025

Functional integrity of the SEL1L-HRD1 complex is critical for ERAD and organismal viability

Xiawei Zhang, Liangguang Leo Lin, Linxiu Pan…·Ling Qi

This paper shows that the SEL1L-HRD1 complex is essential for ERAD function and neonatal survival in mice, with specific mutations causing lethal defects.

DOI 10.1101/2025.08.01.668162

mouseexperimental assay

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