Author

Brent Pederson

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Liangguang Leo LiniD· 3 shared Ling QiiD· 3 shared Mauricio TorresiD· 3 shared Abigail TomlinsoniD· 1 shared Alan C. RuppiD· 1 shared Ali NajiiD· 1 shared Amara Bugarin-Lapuz· 1 shared Andrew J. ScottiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

Liangguang Leo LinORCID

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3 papers

Recent·Most cited

SEL1L-HRD1 ER-Associated Degradation Facilitates Prohormone Convertase 2 Maturation and Glucagon Production in Islet α Cells

Wenzhen Zhu, Linxiu Pan, Xianwei Cui, Anna Chiara Russo, ROHIT RAY, Brent Pederson, Xiaoqiong Wei, Liangguang Leo Lin, Mauricio Torres, Hannah Hafner, Brigid Ellen Gregg, Neha Shrestha, Chengyang Liu, Ali Naji, Peter R. Arvan, , Rachel B. Reinert

This study identifies SEL1L-HRD1 ERAD as a regulator of PC2 maturation and glucagon production in islet α cells by degrading misfolded proPC2.

Nature Communications · Feb 25, 2026Peer-reviewedCell Biology

Neuronal SEL1L-HRD1 ERAD regulates one-carbon metabolism and is essential for motor function and survival

Mauricio Torres, You Lu, Brent Pederson, Hui Wang, Anna Gretzinger, Liangguang Leo Lin, Jiwon Hwang, Alan C. Rupp, Abigail Tomlinson, Andrew J. Scott, Zhen Zhao, Daniel Richard Wahl, Martin Grosvenor Myers, Costas Andreas Lyssiotis, Ling Qi

This study shows that neuronal SEL1L-HRD1 ERAD is critical for one-carbon metabolism, motor function, and survival, with loss leading to severe neurological defects.

bioRxiv · Jun 16, 2025 · PreprintCell Biology

Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Causes Progressive Cerebellar Ataxia in Mice

Mauricio Torres, Hui Wang, Brent Pederson, Liangguang Leo Lin, Huilun Helen Wang, Amara Bugarin-Lapuz, Zhen Zhao, Ling Qi

This study shows that SEL1L-HRD1 ERAD is essential for Purkinje cell function and causes progressive cerebellar ataxia in mice.

JCI Insight · Oct 1, 2024Peer-reviewedNeuroscience