Gang Zhou

This study identifies IL13 as a critical cytokine for the antitumor activity of polyfunctional CD4+ T cells modified with constitutively active Stat5, showing its role in enhancing immune responses and tumor control.

This study investigates how PAR2 signaling influences microbial and metabolic changes across the gut-lung axis in response to HDM exposure, showing compartment-specific effects and sex-dependent differences.

This study shows that PDE10A inhibition with ADT-030 suppresses tumor growth by disrupting MAPK signaling and enhancing antitumor immunity through immune cell modulation.

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

This study shows indomethacin enhances chemo-immunotherapy in mice through both COX-dependent and independent mechanisms, including RAS inhibition.

The paper uses single-cell RNA sequencing to study myeloid cell repopulation after chemotherapy in mice, identifying a neutrophil-like monocyte subset with immunosuppressive and pro-tumor activities.