Author

Ogacheko D. Okoko

Augusta University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Gang ZhouiD· 3 shared Huidong ShiiD· 3 shared Catherine C. HedrickiD· 2 shared Gary Anthony PiazzaiD· 2 shared Md Yeashin Gazi· 2 shared Samson Eugin SimoniD· 2 shared Xin Wang· 2 shared Yan Ye· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Gang ZhouORCID

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3 papers

Recent·Most cited

Targeting phosphodiesterase 10A disrupts MAPK signaling pathways in the tumor microenvironment to unleash antitumor immunity

Md Yeashin Gazi, Yan Ye, Ogacheko D. Okoko, Xin Wang, Samson Eugin Simon, Ahmad Alimadadi, Nandeeni Suryawanshi, Catlin Brandle, Mei Zheng, Lirong Pei, Khalda Fadlalla, Adam B. Keeton, Yulia Y. Maxuitenko, Xi Chen, Austin W.T. Chiang, , Gang Zhou

This study shows that PDE10A inhibition with ADT-030 suppresses tumor growth by disrupting MAPK signaling and enhancing antitumor immunity through immune cell modulation.

bioRxiv · Feb 28, 2026 · PreprintImmunology

Indomethacin exerts both cyclooxygenase inhibition-dependent and independent mechanisms to enhance chemo-immunotherapy in mice

Ogacheko D. Okoko, Nada S. Aboelella, Yan Ye, X Wang, Samson Eugin Simon, Md Yeashin Gazi, Victor J. Victor J. Enriquez Castro, Mercy Kehinde‐Ige, Caitlin Brandle, Dongwen Lv, David W. Wolff, Catherine C. Hedrick, Gary Anthony Piazza, Huidong Shi, Gang Zhou

This study shows indomethacin enhances chemo-immunotherapy in mice through both COX-dependent and independent mechanisms, including RAS inhibition.

bioRxiv · Jan 8, 2026 · PreprintImmunology

Single-cell transcriptome profiling of the myeloid cells repopulating after chemotherapy identifies a neutrophil-like monocyte subset with pro-tumor activities

Zhi‐Chun Ding, George I. Zhou, Ogacheko D. Okoko, Xin Wang, Locke Johnson Bryan, Gang Zhou, Huidong Shi

The paper uses single-cell RNA sequencing to study myeloid cell repopulation after chemotherapy in mice, identifying a neutrophil-like monocyte subset with immunosuppressive and pro-tumor activities.

bioRxiv · Dec 28, 2024 · PreprintImmunology