This study identifies TOX as a critical regulator of tumor-infiltrating regulatory T cells, showing its role in maintaining immunosuppression and its potential as a therapeutic target.

bioRxiv · Jun 24, 2026 · PreprintImmunology

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma

William Pilcher, Lijun Yao, Edgar Gonzalez‐Kozlova, Yered H. Pita-Juárez, Dimitra Karagkouni, Chaitanya R. Acharya, Marina E. Michaud, Mark Hamilton, Shivani Nanda, Yizhe Song, Kazuhito Sato, Julia T. Wang, Sarthak Satpathy, Yuling Ma, Jessica Schulman, , Manoj Bhasin

The paper characterizes immune microenvironment dysregulation in multiple myeloma using single-cell data and links it to disease progression and patient outcomes.

Nature Cancer · Jan 9, 2026Peer-reviewedGenomics

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

Bérengère Salomé, Haocheng Yu, Daniel L Ranti, Ying‐Chih Wang, C. Bieber, Pierre‐Etienne Gabriel, Igor Duquesne, Trine Strandgaard, B. Hug, Sean Houghton, Hiranmayi Ravichandran, Elliot Merritt, S. Bang, A. Demetriou, Z. Li, , Amir Horowitz

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

bioRxiv · Sep 2, 2024 · PreprintCancer Biology