ImmunologySciencePeer-reviewed
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De novo design and structure of a peptide-centric TCR mimic binding module
Karsten D. Householder, Xinyu Xiang, Kevin M. Jude…·K. Christopher García
A de novo four-helix bundle designed with RFdiffusion and ProteinMPNN binds NY-ESO-1/HLA-A*02 at Kd 9.5 nM, with a 2.05 Å crystal structure and peptide-focused docking.
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