Author

Matthias Obenaus

Stanford MedicineORCID 0000-0002-5090-9162Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

K. Christopher GarcíaiD· 2 shared Xiaojing Tina CheniD· 2 shared Ansuman T. SatpathyiD· 1 shared Arthur DengiD· 1 shared Céline Jasmin PrangeiD· 1 shared Christopher S. McGinnisiD· 1 shared Clara L. PoupaultiD· 1 shared Deepa Waghray· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

K. Christopher GarcíaORCID

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2 papers

Recent·Most cited

T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T-cells

Matthias Obenaus, Clara L. Poupault, Christopher S. McGinnis, Céline Jasmin Prange, Hua Jiang, Leon Su, Xiaojing Tina Chen, Zhuang Miao, Joseph J. Muldoon, Winnie Yao, Deepa Waghray, Qinli Sun, Justin Eyquem, Rogelio Antonio Hernández-López, Ansuman T. Satpathy, , K. Christopher García

Combining TCE therapy with IL-2 enhances TCE efficacy in aggressive small-cell lung cancer and melanoma models with low target antigen density through T cell clonal replacement and CD8+ effector T cell differentiation.

bioRxiv · Jan 27, 2026 · PreprintCancer Biology

De novo design and structure of a peptide-centric TCR mimic binding module

Karsten D. Householder, Xinyu Xiang, Kevin M. Jude, Arthur Deng, Matthias Obenaus, Yang Zhao, Steven C. Wilson, Xiaojing Tina Chen, Nan Wang, K. Christopher García

A de novo four-helix bundle designed with RFdiffusion and ProteinMPNN binds NY-ESO-1/HLA-A*02 at Kd 9.5 nM, with a 2.05 Å crystal structure and peptide-focused docking.

Science · Jul 24, 2025Peer-reviewedImmunology✦ In-depth digest