Author

David F. Edwards

ORCID 0009-0003-4781-0270Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Gi Young LeeiD· 1 shared Jeongmin SongiD· 1 shared Jonathan Z. SextoniD· 1 shared Katherine R. SpindleriD· 1 shared Luíza Antunes de Castro-JorgeiD· 1 shared Mary X O’RiordaniD· 1 shared Michael J. McFaddeniD· 1 shared Simon Sanchez-PaivaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Gi Young LeeORCID

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1 paper

Recent·Most cited

ImmunologyInfection and ImmunityPeer-reviewedJun 15, 2026

Salmonella Typhi asparaginase-dependent activation of GCN2 promotes bacterial killing in murine macrophages

Zachary M. Powers, Michael J. McFadden, Gi Young Lee…·Mary X O’Riordan

This study shows that Salmonella Typhi uses asparaginase to deplete asparagine, activating the GCN2 kinase and the integrated stress response in murine macrophages, which enhances bacterial killing.

DOI 10.1128/iai.00178-26

mouseexperimental assay

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