Michael J. McFadden

This study shows that Salmonella Typhi uses asparaginase to deplete asparagine, activating the GCN2 kinase and the integrated stress response in murine macrophages, which enhances bacterial killing.

This study shows that bacterial metabolites alter C. albicans cell wall composition, affecting antifungal resistance and immune recognition.

This study compares the virulence of Candidozyma auris in different growth phases in mice, finding that log phase causes rapid mortality while stationary phase leads to extended survival.

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

This study shows that Candida albicans activates IRE1 in macrophages through non-canonical mechanisms, enhancing fungicidal activity by promoting phagolysosomal fusion.

The paper shows FTO suppresses proinflammatory ISG expression by inhibiting STAT3 activation during the type I IFN response.