Author

Zachary M. Powers

University of MichiganORCID 0000-0002-3999-4300Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Mary X O’RiordaniD· 2 shared Aaron Wu· 1 shared Aoife O’FarrelliD· 1 shared Arjun RajiD· 1 shared Brian P. GoldspieliD· 1 shared Clémence QueriaultiD· 1 shared Clementina MesarosiD· 1 shared Crystal S. ConniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Mary X O’RiordanORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologyInfection and ImmunityPeer-reviewedJun 15, 2026

Salmonella Typhi asparaginase-dependent activation of GCN2 promotes bacterial killing in murine macrophages

Zachary M. Powers, Michael J. McFadden, Gi Young Lee…·Mary X O’Riordan

This study shows that Salmonella Typhi uses asparaginase to deplete asparagine, activating the GCN2 kinase and the integrated stress response in murine macrophages, which enhances bacterial killing.

DOI 10.1128/iai.00178-26

mouseexperimental assay

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ImmunologybioRxivPreprintJan 20, 2026

Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly

Mikel D. Haggadone, Brian P. Goldspiel, Aoife O’Farrell…·Will Bailis

This study shows that environmental branched-chain amino acids regulate ASC translation and NLRP3 inflammasome assembly through mTOR-dependent translational bursting.

1 citation

mousehuman

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