Author

Kosuke Yamazaki

Tokyo Metropolitan Institute of Medical ScienceORCID 0009-0003-5747-9024Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Hideya KawajiiD· 2 shared Hiroyuki SasanumaiD· 2 shared Kazuto Takayasu· 2 shared Tomohiro Iguchi· 2 shared Yutaka KanohiD· 2 shared Akinori EndoiD· 1 shared Ayaka Onuki· 1 shared Daichi SadatoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

Hideya KawajiORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 21, 2026

BRCA2 loss triggers a downward spiral of genomic instability via ROS-dependent metabolic collapse

Hayato Hirai, Tomohiro Iguchi, Kenji Kitajima…·Hiroyuki Sasanuma

This paper shows BRCA2 loss causes genomic instability through ROS-dependent metabolic collapse, highlighting the role of glutathione metabolism and PARP inhibitors in cell death.

DOI 10.64898/2026.05.15.725601

humanDNA methylation

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Molecular BiologyCell CyclePeer-reviewedFeb 16, 2024

Homologous recombination contributes to the repair of acetaldehyde-induced DNA damages.

Kosuke Yamazaki, Tomohiro Iguchi, Yutaka Kanoh…·Hiroyuki Sasanuma

This study investigates how acetaldehyde-induced DNA damage is repaired, finding that homologous recombination and TDP1/TDP2 play critical roles in repair efficiency.

7 citations

humanDNA methylation

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