Author

Jadon Compher

Scripps Research InstituteORCID 0009-0003-6080-1280Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Jeffery W. KellyiD· 3 shared Mireya Almaraz· 3 shared Sergio R. LabraiD· 3 shared Stuart A. LiptoniD· 3 shared Akhil PrabhavalkariD· 2 shared Anthony BalistreriiD· 2 shared Christine BaaliD· 2 shared Claudia Cedeño KwongiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Jeffery W. KellyORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 2, 2026

Autophagy activator AA-20 engages CDK5 to promote lipophagy and improve neurodegeneration-associated phenotypes

Ee Phie Tan, Lydia Ambaye, Anne-Laure Mahul-Mellier…·Jeffery W. Kelly

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

DOI 10.64898/2026.10.30.760220

humanmouse

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NeurosciencebioRxivPreprintMay 14, 2026

Molecular and Structural Characterization Reveals Divergent Extracellular Vesicle Profiles Between Wild Type and Alzheimer's Disease Cerebrocortical Organoids

Anthony Balistreri, Natalie Turner, Jadon Compher…·Jeffery W. Kelly

The paper characterizes extracellular vesicles from Alzheimer's disease and wild-type cerebrocortical organoids, finding differences in size, membrane structure, and proteomic content.

DOI 10.64898/2026.05.13.724352

humanproteomics

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NeuroscienceAdvanced SciencePeer-reviewedJan 27, 2026

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids

Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar…·Stuart A. Lipton

This study uses human iPSC-derived cortical organoids to model familial Alzheimer's disease and shows that autophagy activators reduce pathological Tau and Aβ accumulation and rescue synaptic loss.

8 citationstop 1%

humanscRNA-seq

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