Emma C. McKay

Spectronaut-nf is a Nextflow pipeline that enables parallel processing of DIA proteomics data on HPC systems, reducing analysis time compared to single workstation execution.

This study shows high temperatures inhibit NLRP3 inflammasome activation, identifying NLRP3 as a thermosensor and revealing a temperature-sensitive conformational change in its C-terminal domain.

This study generates and benchmarks iPSC-derived macrophages (iMacs) as a model for human inflammasome signaling, showing they respond to multiple inflammasome stimuli and activate unique pathways.

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.