Sarah U. Tronnes

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

Inhibition of NLRP3 by a CNS-penetrating indazole scaffold

This paper identifies and characterizes BAL-1516, a CNS-penetrating NLRP3 inhibitor that blocks inflammasome formation and shows potential for treating neuroinflammatory diseases.

Glial-derived mitochondrial signals impact neuronal proteostasis and aging.

This study shows glial cells in C. elegans sense mitochondrial stress and signal to neurons to improve protein homeostasis and longevity.

Glia of C. elegans coordinate the heat shock response independent of the neuronal thermosensory circuit and serotonin

This paper shows that glia in C. elegans can induce a heat shock response in peripheral cells, increasing lifespan and stress resistance, independent of neurons and neurotransmitters.

A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.

This study identifies a non-canonical UPRER pathway that extends lifespan through ER remodeling and lipophagy, independent of chaperone function.