Agnieszka K. Bronowska

This study shows that AMPK senses NAD levels, with NAD binding to the gamma subunit and modulating AMPK activity, which affects metabolic pathways like mTORC1 and autophagy.

This paper identifies the quinone-binding pocket of SaMhqR and elucidates its mechanism of inactivation through structural and mutational analyses.

This study shows high temperatures inhibit NLRP3 inflammasome activation, identifying NLRP3 as a thermosensor and revealing a temperature-sensitive conformational change in its C-terminal domain.

This study uses molecular dynamics simulations to show how calcium ions influence the formation of hetero- and homotrimers of type I collagen, explaining the conditions under which homotrimers form.