Author

Aditi Deshpande

University of California, San FranciscoORCID 0000-0002-5184-5658Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Assem DuisembekovaiD· 2 shared Bénédicte F. PyiD· 2 shared Dominic FerberiD· 2 shared George D. HartmaniD· 2 shared Hannes ButhmanniD· 2 shared Inga V. HochheiseriD· 2 shared Jane TorpiD· 2 shared Kevin WilhelmseniD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Assem DuisembekovaORCID

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3 papers

Recent·Most cited

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

Kevin Wilhelmsen, Aditi Deshpande, Sarah U. Tronnes, Maitriyee Mahanta, MATTHEW BANICKI, MARY COCHRAN, Samantha Cowdin, Kristen Fortney, George D. Hartman, Robert E. Hughes, Rusty L. Montgomery, CLAUDIA PORTILLO, Paul D. Rubin, Taiz Salazar, Yan Wang, , Rebecca C. Coll

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

The Journal of Experimental Medicine · Jul 24, 2025Peer-reviewedImmunology

Inhibition of NLRP3 by a CNS-penetrating indazole scaffold

Jane Torp, Dominic Ferber, Hannes Buthmann, Gregor Hagelueken, Aditi Deshpande, George D. Hartman, Robert E. Hughes, Taiz Salazar, Sarah U. Tronnes, Assem Duisembekova, Michael Marleaux, Inga V. Hochheiser, Rebecca C. Coll, Rusty L. Montgomery, Kristen Fortney, , Matthias Geyer

This paper identifies and characterizes BAL-1516, a CNS-penetrating NLRP3 inhibitor that blocks inflammasome formation and shows potential for treating neuroinflammatory diseases.

bioRxiv · Jul 1, 2025 · PreprintImmunology

TAOK2 Drives Opposing Cilia Length Deficits in 16p11.2 Deletion and Duplication Carriers

Amy Ferreccio, Sujin Byeon, Moira Cornell, Juan A. Osés-Prieto, Aditi Deshpande, Lauren A. Weiss, Alma L. Burlingame, Smita Yadav

The paper identifies TAOK2 as a regulator of primary cilium length in 16p11.2 CNV carriers, showing opposing effects in deletion and duplication cases.

bioRxiv · Oct 7, 2024 · PreprintNeuroscience