Heriberto Marquez

This study uses genome-scale CRISPR base editing in yeast to assess the functional effects of 308,461 variants, identifying 18,009 with significant growth impacts.

This paper introduces a 96-well liquid format for high-throughput QTL mapping in yeast, enabling efficient analysis of multiple crosses and environmental conditions.

The paper develops a pooled selection platform to map modifiers of RNAi gene knockdown effects in C. elegans, identifying two classes of QTL influencing RNAi responses.

This study identifies context-specific eQTLs and their dynamic effects on gene expression in yeast under acute environmental stress, linking genetic variation to physiological adaptation.

The paper identifies a new TA system in C. elegans with divergent toxin alleles suppressed by distinct mechanisms, including piRNA-mediated silencing in the N2 haplotype.

This paper introduces a method to induce targeted recombination in C. elegans using Cas9, enabling high-resolution genetic mapping in species with low natural recombination rates.