Noah Alexander

This study identifies context-specific eQTLs and their dynamic effects on gene expression in yeast under acute environmental stress, linking genetic variation to physiological adaptation.

The paper maps eQTLs in yeast using single-cell RNA sequencing, revealing tradeoffs between growth and reproduction through allele-specific effects on gene expression and cell-cycle progression.

The paper identifies a new TA system in C. elegans with divergent toxin alleles suppressed by distinct mechanisms, including piRNA-mediated silencing in the N2 haplotype.

The paper introduces SVCurator, a crowdsourcing app for evaluating structural variants in the human genome, finding high concordance among curators and with existing benchmarks.

Genome in a Bottle benchmark of 12745 sequence-resolved insertions and deletions of 50 bp or more, integrating 19 calling methods, scores false negatives and false positives alike.

This study improves the detection of m6A in bacterial DNA using nanopore sequencing with a binary classifier, highlighting the importance of read quality and comparing results to PacBio methylation calls.

This study benchmarks eleven metagenomic classifiers using 846 species and evaluates strategies to reduce false positives in taxonomic classification.

This study evaluates nanopore sequencing performance on the ISS, showing no performance decrease and successful genome assembly of bacterial and mammalian samples.

The paper presents extensive sequencing data from seven human genomes to serve as benchmark reference materials for improving sequencing technologies and variant calling.

The paper tests nanopore sequencing in microgravity using a parabolic flight simulator and proposes new computational methods to address sequencing challenges in reduced gravity.