Author

Maciej Dulewicz

University of GothenburgORCID 0000-0002-7149-017XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Jeffrey N. SavasiD· 3 shared Jörg HanriederiD· 3 shared Junyue GeiD· 3 shared Alicja SzadziewskaiD· 2 shared Henrik ZetterbergiD· 2 shared Jack I. WoodiD· 2 shared Kaj BlennowiD· 2 shared Srinivas KoutarapuiD· 2 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersNeuroscience

Jeffrey N. SavasORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer's disease models

Nalini R. Rao, Olivia A. DeGulis, Toshihiro Nomura, SeungEun Lee, Timothy J. Hark, Justin C. Dynes, Emily X. Dexter, Maciej Dulewicz, Junyue Ge, Arun Upadhyay, Eugenio F. Fornasiero, Robert J. Vassar, Jörg Hanrieder, Anis Contractor, Jeffrey N. Savas

The paper discovers that levetiracetam prevents Aβ42 production by modulating synaptic vesicle cycling, altering APP localization, and favoring non-amyloidogenic processing in Alzheimer's disease models.

bioRxiv · Oct 28, 2024 · PreprintNeuroscience

Isotope Encoded Chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity

Jack I. Wood, Maciej Dulewicz, Junyue Ge, Katie M. Stringer, Alicja Szadziewska, Sneha Desai, Srinivas Koutarapu, Haady B. Hajar, Kaj Blennow, Henrik Zetterberg, Damian M. Cummings, Jeffrey N. Savas, Frances A. Edwards, Jörg Hanrieder

This paper uses isotope-encoded mass spectrometry imaging and single plaque transcriptomics to track Aβ plaque maturation and its impact on synaptic function and toxicity in Alzheimer's disease.

bioRxiv · Oct 8, 2024 · PreprintNeuroscience

Chemical imaging signatures delineate heterogeneous amyloid plaque populations across the Alzheimers disease spectrum

Srinivas Koutarapu, Junyue Ge, Maciej Dulewicz, Meera Srikrishna, Alicja Szadziewska, Jack I. Wood, Kaj Blennow, Henrik Zetterberg, Wojciech Michno, Natalie Sarah Ryan, Tammaryn Lashley, Jeffrey N. Savas, Michael Schöll, Jörg Hanrieder

This study uses chemical imaging and deep learning to identify distinct amyloid plaque subtypes in Alzheimer's disease, revealing differences in Aβ composition and associations with disease progression.

bioRxiv · Jun 3, 2024 · PreprintNeuroscience