Author

Manson Jim

Broad InstituteORCID 0009-0004-2972-6582Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Assay:scRNA-seq· 1 Research Focus:software / tool· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Fei CheniD· 2 shared Xi Dawn CheniD· 2 shared Ada FangiD· 1 shared Adam GayosoiD· 1 shared Andrea Navarro TorresiD· 1 shared Anisha LaumasiD· 1 shared Anne MottramiD· 1 shared Anne O’Donnell‐LuriaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Fei ChenORCID

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2 papers

Recent·Most cited

AlphaGenome Atlas: in silico mutagenesis of the entire human genome improves prioritization and interpretation of non-coding variants

Lead authors:, Jun Cheng, Kyle R. Taylor, Lauren Nicolaisen, Joshua Pan, Clare Bycroft, Matteo Perino, Tom Ward, Gareth Hawkes, Laura Covill, Melanie Weilert, Raina W. Thomas, Natasha S. Latysheva, Contributing authors:, Manson Jim, , Žiga Avsec

AlphaGenome Atlas predicts regulatory effects of non-coding variants across the human genome, improving their prioritization and interpretation.

medRxiv · Sep 20, 2026 · PreprintGenetic & Genomic Medicine

Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation

Xi Dawn Chen, Manson Jim, Mounica Vallurupalli, Kai Cao, Andrea Navarro Torres, Jing Wesley Leong, Yifan Zhang, David Wollensak, Qiyu Gong, Jing Sun, Mehdi Borji, Gail Schor, Sofia Mrowka, Margaret Hu, Anisha Laumas, , Fei Chen

The paper introduces SPICE, a framework that uses splicing assays and generative design to create cell-specific gene regulation elements for research and therapy.

bioRxiv · Nov 5, 2025 · PreprintMolecular Biology