MicrobiologybioRxivPreprint
Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease PfROM8 and cation channel PfCSC1.
Coralie Boulet, Joyanta K. Modak, Natalie A. Counihan…·Paul R. Gilson
This study identifies M-512 as an agonist of PfROM8 and PfCSC1, which are essential for Plasmodium falciparum growth, and shows that their dysregulation reduces parasite viability.
3 citations