Author

Molly Parkyn Schneider

Burnet InstituteORCID 0000-0002-5491-5455Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alyssa E. BarryiD· 2 shared Brad E. SleebsiD· 2 shared Brendan S. CrabbiD· 2 shared Madeline G. DansiD· 2 shared Paul R. GilsoniD· 2 shared Tania F. de Koning‐WardiD· 2 shared William NguyeniD· 2 shared Zahra RazookiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Alyssa E. BarryORCID

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2 papers

Recent·Most cited

Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease PfROM8 and cation channel PfCSC1.

Coralie Boulet, Joyanta K. Modak, Natalie A. Counihan, Molly Parkyn Schneider, William Nguyen, Madeline G. Dans, Claudia B. G. Barnes, Zahra Razook, Kirsty McCann, Alyssa E. Barry, Brendan S. Crabb, Brad E. Sleebs, Tania F. de Koning‐Ward, Paul R. Gilson

This study identifies M-512 as an agonist of PfROM8 and PfCSC1, which are essential for Plasmodium falciparum growth, and shows that their dysregulation reduces parasite viability.

bioRxiv · Mar 18, 2025 · PreprintMicrobiology

The sulfonylpiperazine MMV020291 prevents red blood cell invasion by the malaria parasite Plasmodium falciparum through interference with actin-1/profilin dynamics

Madeline G. Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Sujaan Das, Molly Parkyn Schneider, Thorey K. Jonsdottir, Mikha Gabriela, Maria R. Gancheva, Christopher J. Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey Ian McFadden, , Paul R. Gilson

This study identifies MMV020291 as a compound that targets actin-1/profilin dynamics in Plasmodium falciparum, inhibiting red blood cell invasion and apicoplast segregation.

bioRxiv · Sep 29, 2022 · PreprintMolecular Biology