Wei Zong

Gene-specific exponent-corrected normalization for library size in bulk RNA-seq

The paper introduces gecco, a gene-specific normalization method for bulk RNA-seq that reduces library size bias while preserving biological signal, improving differential expression and pathway analysis.

Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex

This study identifies cell-type and sex-specific gene expression and electrophysiological rhythms in mouse prefrontal cortex neurons, showing differences in rhythmic transcripts and biological processes between excitatory pyramidal cells and inhibitory PV interneurons.

The ultradian transcriptome of the human prefrontal cortex and abnormalities in schizophrenia

The paper identifies 12-hour ultradian rhythms in the human prefrontal cortex and shows disruptions in schizophrenia affecting genes related to protein processing and mitochondrial function.

Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder

The paper investigates molecular rhythm alterations in the prefrontal cortex and nucleus accumbens of individuals with opioid use disorder, finding distinct rhythmic transcript patterns and associations with sleep and neurotransmitter systems.

Experimental Design and Power Calculation in Omics Circadian Rhythmicity Detection

This paper introduces CircaPower, a statistical method for power calculation in circadian rhythmicity detection, validated through simulations and real data.

CAMO: A molecular congruence analysis framework for evaluating model organisms

CAMO evaluates omics congruence between model organisms and humans by analyzing differential analysis, concordance, pathway investigations, and subnetwork detection.

Transcriptional alterations in opioid use disorder reveal an interplay between neuroinflammation and synaptic remodeling

This study identifies transcriptional changes in opioid use disorder brains, linking neuroinflammation and synaptic remodeling through RNA-seq and integrative analyses.

Circadian- and sex-dependent increases in intravenous cocaine self-administration in Npas2 mutant mice

This study investigates how NPAS2 mutations affect cocaine self-administration in mice, showing sex- and time-of-day-dependent changes in reward and motivation.

Comparative Pathway Integrator: a framework of meta-analytic integration of multiple transcriptomic studies for consensual and differential pathway analysis

The paper introduces CPI, a tool for integrating multiple transcriptomic studies to identify consensual and differential pathway enrichment patterns, and applies it to psychiatric disorder data.