Author

Alexander Heatley

MRC Laboratory of Molecular BiologyORCID 0009-0004-0789-2467Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Ceara Harper· 1 shared Elsje G. OtteniD· 1 shared Felix RandowiD· 1 shared Jacqueline HankinsoniD· 1 shared Katerina NaydenovaiD· 1 shared Keith B. BoyleiD· 1 shared Kendra E. LeighiD· 1 shared Matthew C. J. YipiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ceara Harper

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1 paper

Recent·Most cited

ZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers

Katerina Naydenova, Thomas Mund, Matthew C. J. Yip, Ceara Harper, Kendra E. Leigh, Jacqueline Hankinson, Keith B. Boyle, Alexander Heatley, Elsje G. Otten, Valeria Lulla, Yorgo Modis, Felix Randow

This study identifies ZNFX1 as a multifunctional enzyme in innate immunity that couples RNA sensing to ubiquitin signaling and assembles into higher-order structures for signal amplification.

Molecular Cell · Oct 1, 2026Peer-reviewedBiochemistry