Elsje G. Otten

ZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers

This study identifies ZNFX1 as a multifunctional enzyme in innate immunity that couples RNA sensing to ubiquitin signaling and assembles into higher-order structures for signal amplification.

Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213

This study shows Shigella flexneri uses IpaH1.4 to degrade RNF213 and prevent LPS ubiquitylation, evading host antibacterial autophagy.

Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213

This study identifies how RNF213 recognizes diverse pathogens through enzymatic amplification of cooperative recruitment.