Author

Ceara Harper

MRC Laboratory of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Elsje G. OtteniD· 2 shared Felix RandowiD· 2 shared Katerina NaydenovaiD· 2 shared Keith B. BoyleiD· 2 shared Matthew C. J. YipiD· 2 shared Alexander HeatleyiD· 1 shared Ana Crespillo-CasadoiD· 1 shared Harmit Singh MalikiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

Elsje G. OttenORCID

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2 papers

Recent·Most cited

ZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers

Katerina Naydenova, Thomas Mund, Matthew C. J. Yip, Ceara Harper, Kendra E. Leigh, Jacqueline Hankinson, Keith B. Boyle, Alexander Heatley, Elsje G. Otten, Valeria Lulla, Yorgo Modis, Felix Randow

This study identifies ZNFX1 as a multifunctional enzyme in innate immunity that couples RNA sensing to ubiquitin signaling and assembles into higher-order structures for signal amplification.

Molecular Cell · Oct 1, 2026Peer-reviewedBiochemistry

Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213

Ana Crespillo-Casado, Prathyush Pothukuchi, Katerina Naydenova, Matthew C. J. Yip, Janet M. Young, Jérôme Boulanger A, Vimisha Dharamdasani, Ceara Harper, Pierre‐Mehdi Hammoudi, Elsje G. Otten, Keith B. Boyle, Mayuri Gogoi, Harmit Singh Malik, Felix Randow

This study identifies how RNF213 recognizes diverse pathogens through enzymatic amplification of cooperative recruitment.

EMBO Reports · Oct 7, 2024Peer-reviewedMolecular Biology