Pan-viral ORFs discovery using Massively Parallel Ribosome Profiling
Shira Weingarten-Gabbay, Matthew R. Bauer, Alexandra C. Stanton, Yingpu Yu, Catherine A. Freije, Nicole L. Welch, Chloe K. Boehm, Susan Klaeger, Eva K. Verzani, Daniel López, Lisa E. Hensley, Karl R. Clauser, Steven A. Carr, Jennifer G. Abelin, Charles M. Rice, Pardis Christine Sabeti
This study uses Massively Parallel Ribosome Profiling to identify thousands of viral ORFs, including non-canonical ones, and shows their impact on HLA-I peptides and protein synthesis regulation.
Science · Jun 12, 2025Peer-reviewedSystems Biology