Nicole L. Welch

Pan-viral ORFs discovery using Massively Parallel Ribosome Profiling

This study uses Massively Parallel Ribosome Profiling to identify thousands of viral ORFs, including non-canonical ones, and shows their impact on HLA-I peptides and protein synthesis regulation.

Model-directed generation of CRISPR-Cas13a guide RNAs designs artificial sequences that improve nucleic acid detection

This paper designs artificial CRISPR-Cas13a guide RNAs using model-directed algorithms, showing improved sensitivity and variant discrimination in nucleic acid detection.

Widespread Horizontal Gene Transfer Among Animal Viruses

This study explores horizontal gene transfer among animal viruses by analyzing sequencing data, revealing chimeric structures and new viral groups.

Designing viral diagnostics with model-based optimization

This paper designs viral diagnostics using a model-based optimization approach, achieving higher sensitivity and specificity across viral genomic variation.

Expression of short hairpin RNAs using the compact architecture of retroviral microRNA genes

The paper develops a compact shRNA expression system using retroviral miRNA gene architecture, reducing coding space needed for shRNA expression by over two-fold compared to U6/H1 promoters.