Author

Chloe K. Boehm

Broad InstituteORCID 0000-0002-6136-3257Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Catherine A. FreijeiD· 3 shared Charles M. RiceiD· 2 shared Lisa E. HensleyiD· 2 shared Pardis Christine SabetiiD· 2 shared Yingpu YuiD· 2 shared Aaron E. LiniD· 1 shared Abdulwasiu Bolaji TiamiyuiD· 1 shared Adam D. NitidoiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

Catherine A. FreijeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors

Catherine A. Freije, Georgios Dangas, Antonis Athanasiadis, Evgenia Moschogianni, Madeleine K Sanders, Allan Henrique Depieri Cataneo, Chloe K. Boehm, Maria Bousali, Dar-Yin Li, Sooyoung Lee, Guillaume Cornelis, Gary Lo, Leah B. Soriaga, Amalio Telenti, Julia di Iulio, , Eleftherios Michailidis

The paper identifies HBV host factors using CRISPR screens and human liver chimeric mice, finding that EXOC1 is antiviral and ZCCHC14 is proviral.

bioRxiv · Jul 24, 2026 · PreprintMicrobiology

Pan-viral ORFs discovery using Massively Parallel Ribosome Profiling

Shira Weingarten-Gabbay, Matthew R. Bauer, Alexandra C. Stanton, Yingpu Yu, Catherine A. Freije, Nicole L. Welch, Chloe K. Boehm, Susan Klaeger, Eva K. Verzani, Daniel López, Lisa E. Hensley, Karl R. Clauser, Steven A. Carr, Jennifer G. Abelin, Charles M. Rice, Pardis Christine Sabeti

This study uses Massively Parallel Ribosome Profiling to identify thousands of viral ORFs, including non-canonical ones, and shows their impact on HLA-I peptides and protein synthesis regulation.

Science · Jun 12, 2025Peer-reviewedSystems Biology

Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time

Kayla G. Barnes, Anna E. Lachenauer, Adam D. Nitido, Sameed M. Siddiqui, Robin Gross, Brett F. Beitzel, Katherine J. Siddle, Catherine A. Freije, Bonnie Dighero-Kemp, Samar B. Mehta, Amber Carter, Jessica N. Uwanibe, Fehintola Victoria Ajogbasile, Testimony Jesupamilerin Olumade, Ikponmwosa Odia, , Pardis Christine Sabeti

This paper develops CRISPR-Cas13a-based diagnostics for real-time detection of Ebola and Lassa viruses in field settings, demonstrating sensitivity and usability in clinical samples.

Nature Communications · Aug 17, 2020Peer-reviewedMolecular Biology