NeurosciencebioRxivPreprint
Molecular glue degraders enhance CAPRIN1-dependent lysosomal degradation of APP in Alzheimer disease
Sung Han Jung, Raktim N. Roy, Xu Wang…·Chunhai Hao
The paper identifies molecular glue degraders that selectively degrade APP via CAPRIN1-dependent lysosomal pathway in neurons, reducing Aβ production in AD mouse models.